Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83636
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
12500±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83636
Synonyms:
(5Z)-5-[(6-methoxy-1,3-benzodioxol-5-yl)methylene]-3-propargyl-thiazolidine-2,4-quinone | (5Z)-5-[(6-methoxy-1,3-benzodioxol-5-yl)methylidene]-3-prop-2-ynyl-1,3-thiazolidine-2,4-dione | (5Z)-5-[(6-methoxy-1,3-benzodioxol-5-yl)methylidene]-3-prop-2-ynylthiazolidine-2,4-dione | 5-[(6-methoxy-1,3-benzodioxol-5-yl)methylene]-3-(2-propyn-1-yl)-1,3-thiazolidine-2,4-dione | MLS001163621 | SMR000497435 | cid_1315178
Type:
Small organic molecule
Emp. Form.:
C15H11NO5S
Mol. Mass.:
317.317
SMILES:
COc1cc2OCOc2cc1\C=C1/SC(=O)N(CC#C)C1=O
Structure:
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