Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83673
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
9870±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83673
Synonyms:
3-(5-methylfuran-2-yl)carbonyl-2-(4-methylphenyl)-1-(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)-4-oxidanyl-2H-pyrrol-5-one | 3-hydroxy-4-(5-methyl-2-furoyl)-1-[5-(methylthio)-1,3,4-thiadiazol-2-yl]-5-(p-tolyl)-3-pyrrolin-2-one | 4-hydroxy-3-(5-methylfuran-2-carbonyl)-2-(4-methylphenyl)-1-(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)-2H-pyrrol-5-one | 4-hydroxy-3-[(5-methyl-2-furanyl)-oxomethyl]-2-(4-methylphenyl)-1-[5-(methylthio)-1,3,4-thiadiazol-2-yl]-2H-pyrrol-5-one | MLS001140748 | SMR000650392 | cid_4902571
Type:
Small organic molecule
Emp. Form.:
C20H17N3O4S2
Mol. Mass.:
427.497
SMILES:
CSc1nnc(s1)N1C(C(C(=O)c2ccc(C)o2)C(=O)C1=O)c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: