Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83467
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83467
Synonyms:
(3-Cyano-5,7-dimethyl-quinolin-2-ylsulfanyl)-acetic acid methyl ester | 2-[(3-cyano-5,7-dimethyl-2-quinolinyl)thio]acetic acid methyl ester | 2-[(3-cyano-5,7-dimethyl-2-quinolyl)thio]acetic acid methyl ester | MLS000031388 | SMR000005252 | cid_648917 | methyl 2-(3-cyano-5,7-dimethyl-quinolin-2-yl)sulfanylethanoate | methyl 2-(3-cyano-5,7-dimethylquinolin-2-yl)sulfanylacetate
Type:
Small organic molecule
Emp. Form.:
C15H14N2O2S
Mol. Mass.:
286.349
SMILES:
COC(=O)CSc1nc2cc(C)cc(C)c2cc1C#N
Structure:
Search PDB for entries with ligand similarity: