Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM52261
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
19200±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM52261
Synonyms:
(4Z)-2-[(E)-2-(3-nitrophenyl)ethenyl]-4-(phenylazanylmethylidene)-1,3-oxazol-5-one | (4Z)-4-(anilinomethylene)-2-[(E)-2-(3-nitrophenyl)vinyl]-2-oxazolin-5-one | (4Z)-4-(anilinomethylidene)-2-[(E)-2-(3-nitrophenyl)ethenyl]-1,3-oxazol-5-one | (4Z)-4-(anilinomethylidene)-2-[(E)-2-(3-nitrophenyl)ethenyl]-5-oxazolone | MLS000521377 | SMR000131785 | cid_6935000
Type:
Small organic molecule
Emp. Form.:
C18H13N3O4
Mol. Mass.:
335.3135
SMILES:
Oc1oc(\C=C\c2cccc(c2)[N+]([O-])=O)nc1\C=N\c1ccccc1
Structure:
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