Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83564
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
11900±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83564
Synonyms:
(E)-2-Cyano-3-[5-(4-difluoromethylsulfanyl-phenyl)-furan-2-yl]-acrylic acid isopropyl ester | (E)-2-cyano-3-[5-[4-(difluoromethylthio)phenyl]-2-furanyl]-2-propenoic acid propan-2-yl ester | (E)-2-cyano-3-[5-[4-(difluoromethylthio)phenyl]-2-furyl]acrylic acid isopropyl ester | MLS000591191 | SMR000218006 | cid_1527415 | propan-2-yl (E)-2-cyano-3-[5-[4-(difluoromethylsulfanyl)phenyl]furan-2-yl]prop-2-enoate | propan-2-yl (E)-3-[5-[4-[bis(fluoranyl)methylsulfanyl]phenyl]furan-2-yl]-2-cyano-prop-2-enoate
Type:
Small organic molecule
Emp. Form.:
C18H15F2NO3S
Mol. Mass.:
363.378
SMILES:
CC(C)OC(=O)C(=C\c1ccc(o1)-c1ccc(SC(F)F)cc1)\C#N
Structure:
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