Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM49857
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
29500±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM49857
Synonyms:
7-(2-oxidanylidenepropylsulfanyl)-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline-8-carbonitrile | 7-(2-oxopropylsulfanyl)-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline-8-carbonitrile | 7-(2-oxopropylthio)-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline-8-carbonitrile | 7-(acetonylthio)-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline-8-carbonitrile | MLS000706370 | SMR000288422 | cid_1433869
Type:
Small organic molecule
Emp. Form.:
C15H12N2O3S
Mol. Mass.:
300.332
SMILES:
CC(=O)CSc1nc2cc3OCCOc3cc2cc1C#N
Structure:
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