Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83618
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
7910±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83618
Synonyms:
4-methyl-N-(1-methylpropylideneamino)-3-nitro-benzenesulfonamide | MLS000775595 | N-(butan-2-ylideneamino)-4-methyl-3-nitro-benzenesulfonamide | N-(butan-2-ylideneamino)-4-methyl-3-nitrobenzenesulfonamide | SMR000370481 | cid_3910353
Type:
Small organic molecule
Emp. Form.:
C11H15N3O4S
Mol. Mass.:
285.32
SMILES:
CC[C+](C)[N-]NS(=O)(=O)c1ccc(C)c(c1)[N+]([O-])=O
Structure:
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