Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM53082
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
8150±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM53082
Synonyms:
4-Chloro-7-methyl-3-(phenyl-hydrazono)-1,3-dihydro-indol-2-one | 4-chloranyl-7-methyl-3-(2-phenylhydrazinyl)indol-2-one | 4-chloro-7-methyl-3-(2-phenylhydrazinyl)indol-2-one | 4-chloro-7-methyl-3-(N'-phenylhydrazino)indol-2-one | 4-chloro-7-methyl-3-(phenylhydrazo)-2-indolone | MLS001209448 | SMR000513316 | cid_5752240
Type:
Small organic molecule
Emp. Form.:
C15H12ClN3O
Mol. Mass.:
285.728
SMILES:
Cc1ccc(Cl)c2=C(NNc3ccccc3)C(=O)N=c12 |c:6,t:19|
Structure:
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