Reaction Details Report a problem with these data
Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83850
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59610±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83850
Synonyms:
MLS002702313 | N-[2-(dimethylamino)ethyl]-9-fluoranyl-phenazine-1-carboxamide;hydrochloride | N-[2-(dimethylamino)ethyl]-9-fluoro-1-phenazinecarboxamide;hydrochloride | N-[2-(dimethylamino)ethyl]-9-fluoro-phenazine-1-carboxamide;hydrochloride | N-[2-(dimethylamino)ethyl]-9-fluorophenazine-1-carboxamide;hydrochloride | SMR001565875 | cid_386521
Type:
Small organic molecule
Emp. Form.:
C17H17FN4O
Mol. Mass.:
312.3415
SMILES:
CN(C)CCNC(=O)c1cccc2nc3cccc(F)c3nc12
Structure:
Search PDB for entries with ligand similarity: