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Target
Aurora kinase B
Ligand
BDBM84650
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
pH
7.5±0
Temperature
277.15±0 K
IC50
1.62e+4±n/a nM
Citation
 Sardon, T; Cottin, T; Xu, J; Giannis, A; Vernos, I Development and biological evaluation of a novel aurora A kinase inhibitor. Chembiochem 10:464-78 (2009) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM84650
Synonyms:
TC-34
Type:
Small organic molecule
Emp. Form.:
C20H23N3O2
Mol. Mass.:
337.4155
SMILES:
CC(C)Nc1nc(nc2ccc(C=CC(C)(C)O)cc12)-c1ccco1
Structure:
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