Reaction Details Report a problem with these data
Target
Toll-like receptor 5
Ligand
BDBM50239681
Substrate
n/a
Meas. Tech.
ChEMBL_1666668 (CHEMBL4016464)
EC50
>100000±n/a nM
Citation
 Zhang, L; Dewan, V; Yin, H Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities. J Med Chem 60:5029-5044 (2017) [PubMed]  Article 
Target
Name:
Toll-like receptor 5
Synonyms:
TIL3 | TLR5 | TLR5_HUMAN | Toll-like receptor 5 | Toll/interleukin-1 receptor-like protein 3
Type:
PROTEIN
Mol. Mass.:
97834.90
Organism:
Homo sapiens
Description:
ChEMBL_105414
Residue:
858
Sequence:
MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS
  
Inhibitor
Name:
BDBM50239681
Synonyms:
CHEMBL4074408
Type:
Small organic molecule
Emp. Form.:
C27H24N2O8
Mol. Mass.:
504.4881
SMILES:
[O-][N+](=O)c1ccc(COc2cc3OC4(CCOCC4)C=Cc3cc2OCc2ccc(cc2)[N+]([O-])=O)cc1 |c:20|
Structure:
Search PDB for entries with ligand similarity: