Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50304633
Substrate
n/a
Meas. Tech.
ChEBML_1669045
Ki
122±n/a nM
Citation
 Yu, J; Ahn, S; Kim, HJ; Lee, M; Ahn, S; Kim, J; Jin, SH; Lee, E; Kim, G; Cheong, JH; Jacobson, KA; Jeong, LS; Noh, M Polypharmacology of N J Med Chem 60:7459-7475 (2017) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50304633
Synonyms:
9-(5'-Cyclobutylaminocarbonyl-4'-thio-beta-D-ribofuranosyl)-N6-(3-iodobenzyl)adenine | CHEMBL594625
Type:
Small organic molecule
Emp. Form.:
C21H23IN6O3S
Mol. Mass.:
566.415
SMILES:
O[C@H]1[C@@H](O)[C@@H](S[C@@H]1C(=O)NC1CCC1)n1cnc2c(NCc3cccc(I)c3)ncnc12 |r|
Structure:
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