Reaction Details Report a problem with these data
Target
Serine hydroxymethyltransferase, cytosolic
Ligand
BDBM50243415
Substrate
n/a
Meas. Tech.
ChEMBL_1672777 (CHEMBL4022806)
IC50
>100000±n/a nM
Citation
Fales, KR; Njoroge, FG; Brooks, HB; Thibodeaux, S; Torrado, A; Si, C; Toth, JL; Mc Cowan, JR; Roth, KD; Thrasher, KJ; Frimpong, K; Lee, MR; Dally, RD; Shepherd, TA; Durham, TB; Margolis, BJ; Wu, Z; Wang, Y; Atwell, S; Wang, J; Hui, YH; Meier, TI; Konicek, SA; Geeganage, S Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Can J Med Chem 60:9599-9616 (2017) [PubMed] Article
More Info.:
Target
Name:
Serine hydroxymethyltransferase, cytosolic
Synonyms:
GLYC_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT1 | Serine methylase
Type:
PROTEIN
Mol. Mass.:
53091.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_745716
Residue:
483
Sequence:
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF