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Target
Quinolone resistance protein NorA
Ligand
BDBM50245850
Substrate
n/a
Meas. Tech.
ChEMBL_1676200 (CHEMBL4026343)
IC50
2000±n/a nM
Citation
 Schillaci, D; Spanò, V; Parrino, B; Carbone, A; Montalbano, A; Barraja, P; Diana, P; Cirrincione, G; Cascioferro, S Pharmaceutical Approaches to Target Antibiotic Resistance Mechanisms. J Med Chem 60:8268-8297 (2017) [PubMed]  Article 
Target
Name:
Quinolone resistance protein NorA
Synonyms:
NORA_STAAU | norA
Type:
PROTEIN
Mol. Mass.:
42273.03
Organism:
Staphylococcus aureus
Description:
ChEMBL_961221
Residue:
388
Sequence:
MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVVIVLIEKQHRAKLKEQNM
  
Inhibitor
Name:
BDBM50245850
Synonyms:
CHEMBL4071003
Type:
Small organic molecule
Emp. Form.:
C39H34O14
Mol. Mass.:
726.6789
SMILES:
C[C@@H]1O[C@@H](OC2C(Oc3cc(O)cc(O)c3C2=O)c2ccc(O)cc2)[C@H](OC(=O)\C=C\c2ccc(O)cc2)[C@H](O)[C@H]1OC(=O)\C=C\c1ccc(O)cc1 |r|
Structure:
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