Reaction Details Report a problem with these data
Target
Ribonucleoside-diphosphate reductase subunit M2
Ligand
BDBM50198892
Substrate
n/a
Meas. Tech.
ChEMBL_1677703 (CHEMBL4027846)
IC50
185±n/a nM
Citation
 Huff, SE; Mohammed, FA; Yang, M; Agrawal, P; Pink, J; Harris, ME; Dealwis, CG; Viswanathan, R Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J Med Chem 61:666-680 (2018) [PubMed]  Article 
Target
Name:
Ribonucleoside-diphosphate reductase subunit M2
Synonyms:
RIR2_HUMAN | RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit
Type:
PROTEIN
Mol. Mass.:
44868.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_195255
Residue:
389
Sequence:
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF
  
Inhibitor
Name:
BDBM50198892
Synonyms:
3-AP | 3-aminopyridine-2-carboxaldehyde thiosemicarbazone | Triapine | US10155732, Compound 3-AP
Type:
Small organic molecule
Emp. Form.:
C7H9N5S
Mol. Mass.:
195.245
SMILES:
NC(=S)N\N=C\c1ncccc1N
Structure:
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