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Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM50250631
Substrate
n/a
Meas. Tech.
ChEMBL_1682040 (CHEMBL4032317)
Ki
>5450±n/a nM
Citation
 Kurata, H; Kusumi, K; Otsuki, K; Suzuki, R; Kurono, M; Komiya, T; Hagiya, H; Mizuno, H; Shioya, H; Ono, T; Takada, Y; Maeda, T; Matsunaga, N; Kondo, T; Tominaga, S; Nunoya, KI; Kiyoshi, H; Komeno, M; Nakade, S; Habashita, H Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P J Med Chem 60:9508-9530 (2017) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM50250631
Synonyms:
CHEMBL4093489
Type:
Small organic molecule
Emp. Form.:
C27H33NO4
Mol. Mass.:
435.5552
SMILES:
CCCc1ccc(COc2ccc3C(C)=C(CN4CC(C4)C(O)=O)CCc3c2)c(OC)c1 |t:14|
Structure:
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