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Target
Casein kinase II subunit alpha
Ligand
BDBM50252622
Substrate
n/a
Meas. Tech.
ChEMBL_1685043 (CHEMBL4035522)
IC50
370±n/a nM
Citation
 De Fusco, C; Brear, P; Iegre, J; Georgiou, KH; Sore, HF; Hyvönen, M; Spring, DR A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorg Med Chem 25:3471-3482 (2017) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Inhibitor
Name:
BDBM50252622
Synonyms:
CHEMBL4070389
Type:
Small organic molecule
Emp. Form.:
C26H26ClN3O4
Mol. Mass.:
479.955
SMILES:
OC(=O)c1cccc(NC(=O)CCNC(=O)CCNCc2ccc(c(Cl)c2)-c2ccccc2)c1
Structure:
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