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Target
Mu-type opioid receptor
Ligand
BDBM50253136
Substrate
n/a
Meas. Tech.
ChEBML_1685442
Ki
0.833000±n/a nM
Citation
 Hayashida, K; Hirayama, S; Iwai, T; Watanabe, Y; Takahashi, T; Sakai, J; Nakata, E; Yamakawa, T; Fujii, H; Nagase, H Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities. Bioorg Med Chem Lett 27:2742-2745 (2017) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOR-1 | Mor | OPIATE Mu | OPRM_MOUSE | Opioid receptors; mu and delta | Oprm | Oprm1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44431.62
Organism:
MOUSE
Description:
OPIATE Mu OPRM1 MOUSE::P42866
Residue:
398
Sequence:
MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50253136
Synonyms:
CHEMBL4075409
Type:
Small organic molecule
Emp. Form.:
C28H30N2O3
Mol. Mass.:
442.5494
SMILES:
[H][C@]12CN(C3CCC4(O1)C1Cc5ccc(O)cc5C4(CCN1CC=C)C23)C(=O)c1ccccc1 |r,TLB:3:4:18:8.1,2:1:18:5.6.4,6:7:21.20.19:10.17.11,17:18:8.1:5.6.4,16:17:21.20.19:7,THB:19:18:8.1:5.6.4|
Structure:
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