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Target
Carnitine O-palmitoyltransferase 1, muscle isoform
Ligand
BDBM50260112
Substrate
n/a
Meas. Tech.
ChEBML_1692709
IC50
88000±n/a nM
Citation
 Tseng, CC; Noordali, H; Sani, M; Madhani, M; Grant, DM; Frenneaux, MP; Zanda, M; Greig, IR Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy. J Med Chem 60:2780-2789 (2017) [PubMed]  Article 
Target
Name:
Carnitine O-palmitoyltransferase 1, muscle isoform
Synonyms:
CPT1B_RAT | Carnitine palmitoyltransferase 1B | Cpt1b
Type:
PROTEIN
Mol. Mass.:
88241.28
Organism:
Rattus norvegicus
Description:
ChEMBL_887447
Residue:
772
Sequence:
MAEAHQAVAFQFTVTPDGVDFRLSREALRHIYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVVMATVGSNYCKVDISMGLVHCIQRCLPTRYGSYGTPQTETLLSMVIFSTGVWATGIFLFRQTLKLLLSYHGWMFEMHSKTSHATKIWAICVRLLSSRRPMLYSFQTSLPKLPVPSVPATIHRYLDSVRPLLDDEAYFRMESLAKEFQDKIAPRLQKYLVLKSWWATNYVSDWWEEYVYLRGRSPIMVNSNYYAMDFVLIKNTSQQAARLGNTVHAMIMYRRKLDREEIKPVMALGMVPMCSYQMERMFNTTRIPGKETDLLQHLSESRHVAVYHKGRFFKVWLYEGSCLLKPRDLEMQFQRILDDTSPPQPGEEKLAALTAGGRVEWAEARQKFFSSGKNKMSLDTIERAAFFVALDEDSHCYNPDDEASLSLYGKSLLHGNCYNRWFDKSFTLISCKNGQLGLNTEHSWADAPIIGHLWEFVLATDTFHLGYTETGHCVGEPNTKLPPPQRMQWDIPEQCQTAIENSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDKGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVRAMMTGSHKKQDLQDLFRKASEKHQNMYRLAMTGAGIDRHLFCLYIVSKYLGVRSPFLDEVLSEPWSLSTSQIPQFQICMFDPKQYPNHLGAGGGFGPVADHGYGVSYMIAGENTMFFHVSSKLSSSETNALRFGNHIRQALLDIADLFKISKTDS
  
Inhibitor
Name:
BDBM50260112
Synonyms:
CHEMBL4068222
Type:
Small organic molecule
Emp. Form.:
C19H31F4N
Mol. Mass.:
349.4498
SMILES:
FC1(F)CCC(CC1)C(CC1CCCCN1)C1CCC(F)(F)CC1
Structure:
Search PDB for entries with ligand similarity: