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Target
DNA-directed RNA polymerase, mitochondrial
Ligand
BDBM50261285
Substrate
n/a
Meas. Tech.
ChEBML_1695789
IC50
>500000±n/a nM
Citation
 Alexandre, FR; Badaroux, E; Bilello, JP; Bot, S; Bouisset, T; Brandt, G; Cappelle, S; Chapron, C; Chaves, D; Convard, T; Counor, C; Da Costa, D; Dukhan, D; Gay, M; Gosselin, G; Griffon, JF; Gupta, K; Hernandez-Santiago, B; La Colla, M; Lioure, MP; Milhau, J; Paparin, JL; Peyronnet, J; Parsy, C; Pierra Rouvière, C; Rahali, H; Rahali, R; Salanson, A; Seifer, M; Serra, I; Standring, D; Surleraux, D; Dousson, CB The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-?-chloro-2'-?-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors. Bioorg Med Chem Lett 27:4323-4330 (2017) [PubMed]  Article 
Target
Name:
DNA-directed RNA polymerase, mitochondrial
Synonyms:
2.7.7.6 | DNA-directed RNA polymerase, mitochondrial | MtRPOL | POLRMT | RPOM_HUMAN
Type:
PROTEIN
Mol. Mass.:
138671.72
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108039
Residue:
1230
Sequence:
MSALCWGRGAAGLKRALRPCGRPGLPGKEGTAGGVCGPRRSSSASPQEQDQDRRKDWGHVELLEVLQARVRQLQAESVSEVVVNRVDVARLPECGSGDGSLQPPRKVQMGAKDATPVPCGRWAKILEKDKRTQQMRMQRLKAKLQMPFQSGEFKALTRRLQVEPRLLSKQMAGCLEDCTRQAPESPWEEQLARLLQEAPGKLSLDVEQAPSGQHSQAQLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAVMLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIERCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPPVNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEELGAPEALREQPWPLPVQMELGKLLAEMLVQATQMPCSLDKPHRSSRLVPVLYHVYSFRNVQQIGILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDFPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPLGVPVIQPYRLDSKVKQIGGGIQSITYTHNGDISRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS
  
Inhibitor
Name:
BDBM50261285
Synonyms:
CHEMBL4069349
Type:
Small organic molecule
Emp. Form.:
C10H16ClN2O14P3
Mol. Mass.:
516.613
SMILES:
C[C@@]1(Cl)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r|
Structure:
Search PDB for entries with ligand similarity: