Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50261365
Substrate
n/a
Meas. Tech.
ChEBML_1695945
IC50
3800±n/a nM
Citation
Li, K; Ma, T; Cai, J; Huang, M; Guo, H; Zhou, D; Luan, S; Yang, J; Liu, D; Jing, Y; Zhao, L Conjugates of 18?-glycyrrhetinic acid derivatives with 3-(1H-benzo[d]imidazol-2-yl)propanoic acid as Pin1 inhibitors displaying anti-prostate cancer ability. Bioorg Med Chem 25:5441-5451 (2017) [PubMed] Article More Info.:
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Inhibitor
Name:
BDBM50261365
Synonyms:
CHEMBL4070499
Type:
Small organic molecule
Emp. Form.:
C44H61NO5
Mol. Mass.:
683.9588
SMILES:
[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CCC(=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(=O)OCCCn1c(CCC(O)=O)cc2ccccc12 |r,t:15|
Structure:
