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Target
Pancreatic alpha-amylase
Ligand
BDBM50241487
Substrate
n/a
Meas. Tech.
ChEBML_1696961
IC50
>200000±n/a nM
Citation
 Zhang, BW; Xing, Y; Wen, C; Yu, XX; Sun, WL; Xiu, ZL; Dong, YS Pentacyclic triterpenes as?-glucosidase and?-amylase inhibitors: Structure-activity relationships and the synergism with acarbose. Bioorg Med Chem Lett 27:5065-5070 (2017) [PubMed]  Article 
Target
Name:
Pancreatic alpha-amylase
Synonyms:
1,4-alpha-D-glucan glucanohydrolase | AMY2 | AMYP_PIG | Pancreatic α-amylase | Pancreatic α-amylase
Type:
Protein
Mol. Mass.:
57088.07
Organism:
Sus scrofa (Pig)
Description:
P00690
Residue:
511
Sequence:
MKLFLLLSAFGFCWAQYAPQTQSGRTSIVHLFEWRWVDIALECERYLGPKGFGGVQVSPPNENIVVTNPSRPWWERYQPVSYKLCTRSGNENEFRDMVTRCNNVGVRIYVDAVINHMCGSGAAAGTGTTCGSYCNPGNREFPAVPYSAWDFNDGKCKTASGGIESYNDPYQVRDCQLVGLLDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASKHMWPGDIKAVLDKLHNLNTNWFPAGSRPFIFQEVIDLGGEAIQSSEYFGNGRVTEFKYGAKLGTVVRKWSGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKVAVGFMLAHPYGFTRVMSSYRWARNFVNGQDVNDWIGPPNNNGVIKEVTINADTTCGNDWVCEHRWRQIRNMVWFRNVVDGQPFANWWANGSNQVAFGRGNRGFIVFNNDDWQLSSTLQTGLPGGTYCDVISGDKVGNSCTGIKVYVSSDGTAQFSISNSAEDPFIAIHAESKL
  
Inhibitor
Name:
BDBM50241487
Synonyms:
2,3,6,23-tetrahydroxyurs-12-en-28-oic acid | Asiatic acid | CHEMBL404313 | asiantic acid
Type:
Small organic molecule
Emp. Form.:
C30H48O5
Mol. Mass.:
488.6991
SMILES:
C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O |r,c:9|
Structure:
Search PDB for entries with ligand similarity: