Reaction Details Report a problem with these data
Target
Signal peptide peptidase-like 2A
Ligand
BDBM50263010
Substrate
n/a
Meas. Tech.
ChEMBL_1697323 (CHEMBL4048213)
IC50
121±n/a nM
Citation
 Velcicky, J; Bodendorf, U; Rigollier, P; Epple, R; Beisner, DR; Guerini, D; Smith, P; Liu, B; Feifel, R; Wipfli, P; Aichholz, R; Couttet, P; Dix, I; Widmer, T; Wen, B; Brandl, T Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. J Med Chem 61:865-880 (2018) [PubMed]  Article 
Target
Name:
Signal peptide peptidase-like 2A
Synonyms:
3.4.23.- | IMP-3 | Imp3 | Intramembrane protease 3 | Presenilin-like protein 2 | Psl2 | SPP-like 2A | SPP2A_MOUSE | Signal peptide peptidase-like 2A | Sppl2a | Synonyms=Imp3
Type:
PROTEIN
Mol. Mass.:
58131.12
Organism:
Mus musculus
Description:
ChEMBL_117553
Residue:
523
Sequence:
MGLLHSLHAPAAALLWSCLLGLAAAQEAILHASTNGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTALCHLSDIPPDGIRNKAVVVHWGPCHFLEKARIAQEGGAAALLIANNSVLIPSSRNKSTFQNVTVLIAVITQKDFKDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELENMKSVEDAEDRETRKKKDDYLTFSPLTVVVFVVICCIMIVLLYFFYRWLVYVMIAIFCIASSMSLYNCLSALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKLPVVIRVPKLMGYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITVSVVAWSRKEMKKFWKGSSYQVMDHLDYSTNEENPVTTDEQIVQQ
  
Inhibitor
Name:
BDBM50263010
Synonyms:
CHEMBL4100749
Type:
Small organic molecule
Emp. Form.:
C23H25F2N5O3
Mol. Mass.:
457.4731
SMILES:
C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2cccc(F)c2CN2CCCN2C1=O |r|
Structure:
Search PDB for entries with ligand similarity: