Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM50265841
Substrate
n/a
Meas. Tech.
ChEMBL_1700219 (CHEMBL4051201)
Ki
663±n/a nM
Citation
 Fanelli, R; Floquet, N; Besserer-Offroy, É; Delort, B; Vivancos, M; Longpré, JM; Renault, P; Martinez, J; Sarret, P; Cavelier, F Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues. J Med Chem 60:3303-3313 (2017) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM50265841
Synonyms:
CHEMBL4100456
Type:
Small organic molecule
Emp. Form.:
C35H69N9O7Si
Mol. Mass.:
756.064
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C[Si](C)(C)C)C(O)=O |r|
Structure:
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