Reaction Details Report a problem with these data
Target
Lysyl oxidase homolog 3
Ligand
BDBM50266822
Substrate
n/a
Meas. Tech.
ChEMBL_1701355 (CHEMBL4052337)
IC50
1380±n/a nM
Citation
 Rowbottom, MW; Bain, G; Calderon, I; Lasof, T; Lonergan, D; Lai, A; Huang, F; Darlington, J; Prodanovich, P; Santini, AM; King, CD; Goulet, L; Shannon, KE; Ma, GL; Nguyen, K; MacKenna, DA; Evans, JF; Hutchinson, JH Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem 60:4403-4423 (2017) [PubMed]  Article 
Target
Name:
Lysyl oxidase homolog 3
Synonyms:
1.4.3.- | 1.4.3.13 | LOXL | LOXL3 | LOXL3_HUMAN | Lysyl oxidase homolog 3 | Lysyl oxidase-like protein 3 | Synonyms=LOXL
Type:
PROTEIN
Mol. Mass.:
83173.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117594
Residue:
753
Sequence:
MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANRRFERYPGQTSNQII
  
Inhibitor
Name:
BDBM50266822
Synonyms:
CHEMBL4079398
Type:
Small organic molecule
Emp. Form.:
C18H18ClF4N3O3
Mol. Mass.:
435.8
SMILES:
Cl.NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: