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Target
STE20/SPS1-related proline-alanine-rich protein kinase
Ligand
BDBM50267914
Substrate
n/a
Meas. Tech.
ChEMBL_1704121 (CHEMBL4055354)
IC50
49000±n/a nM
Citation
 Ishigami-Yuasa, M; Watanabe, Y; Mori, T; Masuno, H; Fujii, S; Kikuchi, E; Uchida, S; Kagechika, H Development of WNK signaling inhibitors as a new class of antihypertensive drugs. Bioorg Med Chem 25:3845-3852 (2017) [PubMed]  Article 
Target
Name:
STE20/SPS1-related proline-alanine-rich protein kinase
Synonyms:
2.7.11.1 | PS/TK | PSTK1 | Pancreatic serine/threonine-protein kinase | Pask | STE20/SPS1-related proline-alanine-rich protein kinase | STK39_RAT | Serine/threonine-protein kinase 39 | Spak | Ste-20-related kinase | Stk39
Type:
PROTEIN
Mol. Mass.:
60047.97
Organism:
Rattus norvegicus
Description:
ChEMBL_117413
Residue:
553
Sequence:
MAEPSGSPVHVQLPQQAAPVTAAAAAPAAATSAPAPAPAPAAPAAPAPAPAAAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEENPEISVNAGGIPEQIQSLSVHDSQGQPNANEDYREGPCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGAEIPDEVKLIGFAQLSVS
  
Inhibitor
Name:
BDBM50267914
Synonyms:
CHEMBL4067097
Type:
Small organic molecule
Emp. Form.:
C22H18ClN3O2
Mol. Mass.:
391.85
SMILES:
CCOc1ccc2nc3cc(NC(=O)c4ccc(Cl)cc4)ccc3c(N)c2c1
Structure:
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