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Target
Membrane primary amine oxidase
Ligand
BDBM50268064
Substrate
n/a
Meas. Tech.
ChEMBL_1704404 (CHEMBL4055637)
IC50
160±n/a nM
Citation
 Yamaki, S; Koga, Y; Nagashima, A; Kondo, M; Shimada, Y; Kadono, K; Moritomo, A; Yoshihara, K Synthesis and pharmacological evaluation of glycine amide derivatives as novel vascular adhesion protein-1 inhibitors without CYP3A4 and CYP2C19 inhibition. Bioorg Med Chem 25:4110-4122 (2017) [PubMed]  Article 
Target
Name:
Membrane primary amine oxidase
Synonyms:
AOC3_RAT | Amine oxidase, copper containing | Aoc3 | Semicarbazide-sensitive amine oxidase/ Vascular adhesion protein 1 (SSAO/VAP-1) | Vascular adhesion protein 1 (VAP-1)
Type:
Enzyme
Mol. Mass.:
84979.78
Organism:
Rattus norvegicus (Rat)
Description:
O08590
Residue:
763
Sequence:
MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQEMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYPHPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSWSLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQTPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFHSNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAWAEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSPDSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK
  
Inhibitor
Name:
BDBM50268064
Synonyms:
CHEMBL4086699
Type:
Small organic molecule
Emp. Form.:
C19H26Cl2N4O2
Mol. Mass.:
413.341
SMILES:
Cl.Cl.CN(CC(N)=O)Cc1cccc(n1)-c1ccc(cc1)N1CCOCC1
Structure:
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