Reaction Details Report a problem with these data
Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
Ligand
BDBM50269227
Substrate
n/a
Meas. Tech.
ChEMBL_1705765 (CHEMBL4056998)
IC50
4500±n/a nM
Citation
 Zaryanova, EV; Lozinskaya, NA; Beznos, OV; Volkova, MS; Chesnokova, NB; Zefirov, NS Oxindole-based intraocular pressure reducing agents. Bioorg Med Chem Lett 27:3787-3793 (2017) [PubMed]  Article 
Target
Name:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:
Metallothionein-3 | NMOR2 | NQO2 | NQO2_HUMAN | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:
Protein
Mol. Mass.:
25917.25
Organism:
Homo sapiens (Human)
Description:
P16083
Residue:
231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
  
Inhibitor
Name:
BDBM50269227
Synonyms:
CHEMBL4088981
Type:
Small organic molecule
Emp. Form.:
C15H20N2O
Mol. Mass.:
244.3321
SMILES:
CC(=O)NCCc1cn(C)c2c(C)c(C)ccc12
Structure:
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