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Target
Mitogen-activated protein kinase kinase kinase 12
Ligand
BDBM50271212
Substrate
n/a
Meas. Tech.
ChEMBL_1709827 (CHEMBL4119876)
EC50
457±n/a nM
Citation
Patel, S; Meilandt, WJ; Erickson, RI; Chen, J; Deshmukh, G; Estrada, AA; Fuji, RN; Gibbons, P; Gustafson, A; Harris, SF; Imperio, J; Liu, W; Liu, X; Liu, Y; Lyssikatos, JP; Ma, C; Yin, J; Lewcock, JW; Siu, M Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem 60:8083-8102 (2017) [PubMed] Article
More Info.:
Target
Name:
Mitogen-activated protein kinase kinase kinase 12
Synonyms:
2.7.11.25 | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_MOUSE | MAPK-upstream kinase | MUK | Map3k12 | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | Zpk
Type:
PROTEIN
Mol. Mass.:
96078.19
Organism:
Mus musculus
Description:
ChEMBL_118099
Residue:
888
Sequence:
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANSVLQLHEQDTGGPGGATGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPGGLGVGPSAWDACPPALRGLHHDLLLRKMSSSSPDLLSAALGARGRGATGGARDPGSPPPPQGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTAGRGGNRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELPPSQRWPQGPNMRQSLSTFSSENPSDVEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPEREASSLPMQHQDGQGPNPEDSDCDSTELDNSNSIDALRPPASLPP