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Target
Metallo-beta-lactamase type 2
Ligand
BDBM28898
Substrate
n/a
Meas. Tech.
ChEMBL_1711699 (CHEMBL4121748)
IC50
21700±n/a nM
Citation
 Zhang, D; Markoulides, MS; Stepanovs, D; Rydzik, AM; El-Hussein, A; Bon, C; Kamps, JJAG; Umland, KD; Collins, PM; Cahill, ST; Wang, DY; von Delft, F; Brem, J; McDonough, MA; Schofield, CJ Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-?-lactamases. Bioorg Med Chem 26:2928-2936 (2018) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
3.5.2.6 | B2 metallo-beta-lactamase | BLA2_BACCE | Beta-lactamase II | Cephalosporinase | Metallo-beta-lactamase type 2 | Metallo-beta-lactamase type II | Metallothioprotein beta-lactamase II | Penicillinase | Zinc-requiring beta-lactamase II | blm
Type:
PROTEIN
Mol. Mass.:
28099.58
Organism:
Bacillus cereus
Description:
ChEMBL_117940
Residue:
257
Sequence:
MKKNTLLKVGLCVGLLGTIQFVSTISSVQASQKVEKTVIKNETGTISISQLNKNVWVHTELGSFNGEAVPSNGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDVIITHAHADRIGGIKTLKERGIKAHSTALTAELAKKNGYEEPLGDLQTVTNLKFGNMKVETFYPGKGHTEDNIVVWLPQYNILVGGCLVKSTSAKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHGEVGDKGLLLHTLDLLK
  
Inhibitor
Name:
BDBM28898
Synonyms:
2-[(5Z)-5-(1-benzothiophen-3-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid | rhodanine derivative, 57
Type:
Small organic molecule
Emp. Form.:
C14H9NO3S3
Mol. Mass.:
335.421
SMILES:
OC(=O)CN1C(=S)S\C(=C/c2csc3ccccc23)C1=O
Structure:
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