Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM50273970
Substrate
n/a
Meas. Tech.
ChEMBL_1713663 (CHEMBL4123712)
IC50
30000±n/a nM
Citation
 Amblard, F; Zhou, S; Liu, P; Yoon, J; Cox, B; Muzzarelli, K; Kuiper, BD; Kovari, LC; Schinazi, RF Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors. Bioorg Med Chem Lett 28:2165-2170 (2018) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
Protease
Type:
PROTEIN
Mol. Mass.:
19160.00
Organism:
Norovirus Hu/GII.4-2002/WeertE022/2002/NL
Description:
ChEMBL_117792
Residue:
181
Sequence:
APPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQGAKEFFGVPIKQIQVHKSGEFCRLRFPKPIRTDVTGMILEEGAPGGTVATLLIKRSTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYVVIGVHTAAARGGNTVICATQGGEGEATLE
  
Inhibitor
Name:
BDBM50273970
Synonyms:
CHEMBL4128073
Type:
Small organic molecule
Emp. Form.:
C36H44N4O8S
Mol. Mass.:
692.822
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)OCc1ccccc1)C(=O)NC(C[C@@H]1CCNC1=O)C1OC1S(C)(=O)=O |r|
Structure:
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