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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM321267
Substrate
n/a
Meas. Tech.
ChEMBL_1716891 (CHEMBL4131891)
Ki
3.2±n/a nM
Citation
 Donnier-Maréchal, M; Carato, P; Larchanché, PE; Ravez, S; Boulahjar, R; Barczyk, A; Oxombre, B; Vermersch, P; Melnyk, P Synthesis and pharmacological evaluation of benzamide derivatives as potent and selective sigma-1 protein ligands. Eur J Med Chem 138:964-978 (2017) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM321267
Synonyms:
N-[3-(benzylmethylamino)propyl]-4-chlorobenzamide | US10179761, Compound 3.1.10
Type:
Small organic molecule
Emp. Form.:
C18H21ClN2O
Mol. Mass.:
316.825
SMILES:
CN(CCCNC(=O)c1ccc(Cl)cc1)Cc1ccccc1
Structure:
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