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Target
Fusion glycoprotein F0
Ligand
BDBM50276971
Substrate
n/a
Meas. Tech.
ChEBML_1717435
EC50
78±n/a nM
Citation
 Feng, S; Li, C; Chen, D; Zheng, X; Yun, H; Gao, L; Shen, HC Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors. Eur J Med Chem 138:1147-1157 (2017) [PubMed]  Article 
Target
Name:
Fusion glycoprotein F0
Synonyms:
F | Fusion glycoprotein F0
Type:
PROTEIN
Mol. Mass.:
63485.30
Organism:
Human respiratory syncytial virus
Description:
ChEMBL_106144
Residue:
574
Sequence:
MELPILKANAITTILAAVTFCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLMKQELDKYKNAVTELQLLMQSTPAANNRARRELPRFMNYTLNNTKKTNVTLSKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCRISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
  
Inhibitor
Name:
BDBM50276971
Synonyms:
CHEMBL4167137
Type:
Small organic molecule
Emp. Form.:
C20H21ClN4O4S2
Mol. Mass.:
480.988
SMILES:
CS(=O)(=O)CCCn1c(Cn2cc(c3ccncc23)S(C)(=O)=O)nc2cc(Cl)ccc12
Structure:
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