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Target
Solute carrier family 2, facilitated glucose transporter member 4
Ligand
BDBM50277369
Substrate
n/a
Meas. Tech.
ChEMBL_1717903 (CHEMBL4132903)
IC50
11000±n/a nM
Citation
 Wei, C; Bajpai, R; Sharma, H; Heitmeier, M; Jain, AD; Matulis, SM; Nooka, AK; Mishra, RK; Hruz, PW; Schiltz, GE; Shanmugam, M Development of GLUT4-selective antagonists for multiple myeloma therapy. Eur J Med Chem 139:573-586 (2017) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 4
Synonyms:
GLUT-4 | GLUT4 | GLUT4_HUMAN | Glucose transporter type 4, insulin-responsive | SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4
Type:
PROTEIN
Mol. Mass.:
54787.67
Organism:
Homo sapiens
Description:
ChEMBL_102692
Residue:
509
Sequence:
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND
  
Inhibitor
Name:
BDBM50277369
Synonyms:
CHEMBL4160688
Type:
Small organic molecule
Emp. Form.:
C29H28N2O4
Mol. Mass.:
468.5436
SMILES:
COc1ccc(cc1)C(=O)N(Cc1ccncc1)Cc1cccc(OCc2cccc(OC)c2)c1
Structure:
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