Reaction Details Report a problem with these data
Target
Free fatty acid receptor 4
Ligand
BDBM50278672
Substrate
n/a
Meas. Tech.
ChEMBL_1719140 (CHEMBL4134140)
EC50
34±n/a nM
Citation
 Zhang, X; Cai, C; Sui, Z; Macielag, M; Wang, Y; Yan, W; Suckow, A; Hua, H; Bell, A; Haug, P; Clapper, W; Jenkinson, C; Gunnet, J; Leonard, J; Murray, WV Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes. ACS Med Chem Lett 8:947-952 (2017) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 4
Synonyms:
FFAR4 | FFAR4_HUMAN | G-protein coupled receptor 120 | G-protein coupled receptor 129 | G-protein coupled receptor GT01 | G-protein coupled receptor PGR4 | GPR120 | GPR129 | O3FAR1 | Omega-3 fatty acid receptor 1 | PGR4
Type:
PROTEIN
Mol. Mass.:
42256.91
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508994
Residue:
377
Sequence:
MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
  
Inhibitor
Name:
BDBM50278672
Synonyms:
CHEMBL4161536
Type:
Small organic molecule
Emp. Form.:
C22H18F5NO3S
Mol. Mass.:
471.44
SMILES:
CCc1ccc(cc1)-c1nsc(c1COc1c(F)cc(CCC(O)=O)cc1F)C(F)(F)F
Structure:
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