Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50206087
Substrate
n/a
Meas. Tech.
ChEMBL_1721666 (CHEMBL4136666)
Ki
260±n/a nM
Citation
 Dawson, TK; Dziedzic, P; Robertson, MJ; Cisneros, JA; Krimmer, SG; Newton, AS; Tirado-Rives, J; Jorgensen, WL Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett 8:1287-1291 (2017) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50206087
Synonyms:
CHEMBL3897449
Type:
Small organic molecule
Emp. Form.:
C21H18F3N5O4
Mol. Mass.:
461.3939
SMILES:
OC(=O)C(F)(F)F.NCCOc1ccc2nc(ccc2c1)-c1cn(nn1)-c1ccc(O)cc1
Structure:
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