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Target
Carbonic anhydrase 2
Ligand
BDBM50280341
Substrate
n/a
Meas. Tech.
ChEMBL_1721674 (CHEMBL4136674)
Ki
8.2±n/a nM
Citation
 Nocentini, A; Bua, S; Lomelino, CL; McKenna, R; Menicatti, M; Bartolucci, G; Tenci, B; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Supuran, CT Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. ACS Med Chem Lett 8:1314-1319 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50280341
Synonyms:
CHEMBL4174004
Type:
Small organic molecule
Emp. Form.:
C15H17N7O3S
Mol. Mass.:
375.406
SMILES:
Nc1ncnc2n(CC(=O)NCCc3ccc(cc3)S(N)(=O)=O)cnc12
Structure:
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