Reaction Details Report a problem with these data
Target
rRNA adenine N-6-methyltransferase
Ligand
BDBM50291842
Substrate
n/a
Meas. Tech.
ChEBML_1731833
IC50
450±n/a nM
Citation
 Foik, IP; Tuszynska, I; Feder, M; Purta, E; Stefaniak, F; Bujnicki, JM Novel inhibitors of the rRNA ErmC' methyltransferase to block resistance to macrolides, lincosamides, streptogramine B antibiotics. Eur J Med Chem 146:60-67 (2018) [PubMed]  Article 
Target
Name:
rRNA adenine N-6-methyltransferase
Synonyms:
2.1.1.184 | ERMC1_STAAU | Erythromycin resistance protein | Macrolide-lincosamide-streptogramin B resistance protein | ermC | rRNA adenine N-6-methyltransferase
Type:
PROTEIN
Mol. Mass.:
28881.78
Organism:
Staphylococcus aureus
Description:
ChEMBL_117808
Residue:
244
Sequence:
MNEKNIKHSQNFITSKHNIDKIMTNIRLNEHDNIFEIGSGKGHFTLELVKRCNFVTAIEIDHKLCKTTENKLVDHDNFQVLNKDILQFKFPKNQSYKIYGNIPYNISTDIIRKIVFDSIANEIYLIVEYGFAKRLLNTKRSLALLLMAEVDISILSMVPREYFHPKPKVNSSLIRLSRKKSRISHKDKQKYNYFVMKWVNKEYKKIFTKNQFNNSLKHAGIDDLNNISFEQFLSLFNSYKLFNK
  
Inhibitor
Name:
BDBM50291842
Synonyms:
CHEMBL4165736
Type:
Small organic molecule
Emp. Form.:
C17H17Cl2N3OS
Mol. Mass.:
382.307
SMILES:
CC(C)c1ccc(NC(=S)N\N=C\c2cc(Cl)cc(Cl)c2O)cc1
Structure:
Search PDB for entries with ligand similarity: