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Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM15677
Substrate
n/a
Meas. Tech.
ChEMBL_1732059 (CHEMBL4147595)
IC50
390±n/a nM
Citation
 Chollet, A; Maveyraud, L; Lherbet, C; Bernardes-Génisson, V An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors. Eur J Med Chem 146:318-343 (2018) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA
Type:
Enzyme
Mol. Mass.:
28526.00
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
P9WGR1
Residue:
269
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
  
Inhibitor
Name:
BDBM15677
Synonyms:
1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide | Pyrrolidine Carboxamide Compound d11
Type:
Small organic molecule
Emp. Form.:
C17H20Cl2N2O2
Mol. Mass.:
355.259
SMILES:
Clc1cc(Cl)cc(NC(=O)C2CN(C3CCCCC3)C(=O)C2)c1
Structure:
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