Reaction Details Report a problem with these data
Target
Telomeric repeat-binding factor 2
Ligand
BDBM50338557
Substrate
n/a
Meas. Tech.
ChEMBL_1734477 (CHEMBL4150013)
Ki
26800±n/a nM
Citation
 Chen, X; Liu, L; Chen, Y; Yang, Y; Yang, CY; Guo, T; Lei, M; Sun, H; Wang, S Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction. ACS Med Chem Lett 9:507-511 (2018) [PubMed]  Article 
Target
Name:
Telomeric repeat-binding factor 2
Synonyms:
TERF2 | TERF2_HUMAN | TRBF2 | TRF2 | TTAGGG repeat-binding factor 2 | Telomeric DNA-binding protein | Telomeric repeat-binding factor 2
Type:
PROTEIN
Mol. Mass.:
59608.94
Organism:
Homo sapiens
Description:
ChEMBL_118257
Residue:
542
Sequence:
MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN
  
Inhibitor
Name:
BDBM50338557
Synonyms:
CHEMBL4175503
Type:
Small organic molecule
Emp. Form.:
C47H79N9O11
Mol. Mass.:
946.1839
SMILES:
CC(C)C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(O)=O |r|
Structure:
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