Reaction Details Report a problem with these data
Target
Telomeric repeat-binding factor 2
Ligand
BDBM50338563
Substrate
n/a
Meas. Tech.
ChEMBL_1734477 (CHEMBL4150013)
Ki
11200±n/a nM
Citation
 Chen, X; Liu, L; Chen, Y; Yang, Y; Yang, CY; Guo, T; Lei, M; Sun, H; Wang, S Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction. ACS Med Chem Lett 9:507-511 (2018) [PubMed]  Article 
Target
Name:
Telomeric repeat-binding factor 2
Synonyms:
TERF2 | TERF2_HUMAN | TRBF2 | TRF2 | TTAGGG repeat-binding factor 2 | Telomeric DNA-binding protein | Telomeric repeat-binding factor 2
Type:
PROTEIN
Mol. Mass.:
59608.94
Organism:
Homo sapiens
Description:
ChEMBL_118257
Residue:
542
Sequence:
MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN
  
Inhibitor
Name:
BDBM50338563
Synonyms:
CHEMBL4176438
Type:
Small organic molecule
Emp. Form.:
C45H65N7O7
Mol. Mass.:
816.0403
SMILES:
CC(C)C[C@@H]1NC(=O)[C@H](CCCCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC1=O)C(=O)N(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: