Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50378182
Substrate
n/a
Meas. Tech.
ChEMBL_1737958 (CHEMBL4153708)
Ki
6100±n/a nM
Citation
 Podlewska, S; Kafel, R; Lacivita, E; Sata?a, G; Kooistra, AJ; Vass, M; de Graaf, C; Leopoldo, M; Bojarski, AJ; Mordalski, S Structural insights into serotonin receptor ligands polypharmacology. Eur J Med Chem 151:797-814 (2018) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50378182
Synonyms:
CHEMBL4160177
Type:
Small organic molecule
Emp. Form.:
C19H24F3NO
Mol. Mass.:
339.3952
SMILES:
CC(CC(C)(C)c1ccc(C)o1)NCc1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: