Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50378180
Substrate
n/a
Meas. Tech.
ChEMBL_1737956 (CHEMBL4153706)
Ki
330400±n/a nM
Citation
 Podlewska, S; Kafel, R; Lacivita, E; Sata?a, G; Kooistra, AJ; Vass, M; de Graaf, C; Leopoldo, M; Bojarski, AJ; Mordalski, S Structural insights into serotonin receptor ligands polypharmacology. Eur J Med Chem 151:797-814 (2018) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50378180
Synonyms:
CHEMBL4166092
Type:
Small organic molecule
Emp. Form.:
C21H20F2N2O2
Mol. Mass.:
370.3925
SMILES:
O[C@H](CCN1CCc2onc(c2C1)-c1ccc(F)c(F)c1)c1ccccc1 |r|
Structure:
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