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Target
Tyrosine-protein kinase TXK
Ligand
BDBM202141
Substrate
n/a
Meas. Tech.
ChEMBL_1743743 (CHEMBL4178253)
IC50
>10000±n/a nM
Citation
Thakkar, M; Bhuniya, D; Kaduskar, R; Mengawade, T; Naik, K; Salunkhe, V; Bhalerao, A; Kurhade, S; Mavinahalli, J; Jain, V; Petla, R; Avaragolla, S; Ray, S; Rouduri, S; Dhanave, A; De, S; Pathade, V; Tambe, A; Raje, AA; Madgula, V; Joshi, S; Nadeem, A; Bala, M; Umrani, D; Hariharan, N; Kulkarni, B; Mookhtiar, KA Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett 27:1867-1873 (2017) [PubMed] Article
More Info.:
Target
Name:
Tyrosine-protein kinase TXK
Synonyms:
PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK)
Type:
Protein
Mol. Mass.:
61268.80
Organism:
Homo sapiens (Human)
Description:
P42681
Residue:
527
Sequence:
MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW