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Target
Rap guanine nucleotide exchange factor 4
Ligand
BDBM50098793
Substrate
n/a
Meas. Tech.
ChEMBL_1743818 (CHEMBL4178328)
IC50
900±n/a nM
Citation
 Wang, P; Liu, Z; Chen, H; Ye, N; Cheng, X; Zhou, J Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets. Bioorg Med Chem Lett 27:1633-1639 (2017) [PubMed]  Article 
Target
Name:
Rap guanine nucleotide exchange factor 4
Synonyms:
Cgef2 | Cgef2 | EPAC 2 | Epac2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | RPGF4_MOUSE | Rap guanine nucleotide exchange factor 4 | Rapgef4 | cAMP-GEFII | cAMP-dependent Rap1 guanine-nucleotide exchange factor | cAMP-regulated guanine nucleotide exchange factor II
Type:
PROTEIN
Mol. Mass.:
115497.71
Organism:
Mus musculus
Description:
ChEMBL_109832
Residue:
1011
Sequence:
MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
  
Inhibitor
Name:
BDBM50098793
Synonyms:
CHEMBL3593342
Type:
Small organic molecule
Emp. Form.:
C16H13Cl3N4O2
Mol. Mass.:
399.659
SMILES:
CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)c(Cl)c(Cl)c1)\C#N
Structure:
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