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Target
G-protein coupled receptor 4
Ligand
BDBM50450950
Substrate
n/a
Meas. Tech.
ChEMBL_1744231 (CHEMBL4178741)
IC50
21±n/a nM
Citation
 Velcicky, J; Miltz, W; Oberhauser, B; Orain, D; Vaupel, A; Weigand, K; Dawson King, J; Littlewood-Evans, A; Nash, M; Feifel, R; Loetscher, P Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis. J Med Chem 60:3672-3683 (2017) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 4
Synonyms:
G-protein coupled receptor 4 | G-protein coupled receptor 4 (GPR4) | GPR4 | GPR4_HUMAN
Type:
Enzyme
Mol. Mass.:
40994.40
Organism:
Homo sapiens (Human)
Description:
P46093
Residue:
362
Sequence:
MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ
  
Inhibitor
Name:
BDBM50450950
Synonyms:
CHEMBL4217603
Type:
Small organic molecule
Emp. Form.:
C27H37N5O2
Mol. Mass.:
463.615
SMILES:
CCc1nn2c(C)cc(C)nc2c1Cc1ccc(\C=C\CN2CCN(C[C@@H](O)CO)CC2)cc1 |r|
Structure:
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