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Target
Beta-2 adrenergic receptor
Ligand
BDBM50019457
Substrate
n/a
Meas. Tech.
ChEMBL_38486 (CHEMBL652396)
IC50
>10000±n/a nM
Citation
 Wise, LD; Butler, DE; DeWald, HA; Lustgarten, D; Coughenour, LL; Downs, DA; Heffner, TG; Pugsley, TA (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents. J Med Chem 29:1628-37 (1986) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2_RAT | Adrb2 | Adrb2r | Adrenergic receptor beta
Type:
PROTEIN
Mol. Mass.:
46896.26
Organism:
Rattus norvegicus
Description:
ChEMBL_38603
Residue:
418
Sequence:
MEPHGNDSDFLLAPNGSRAPGHDITQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWNFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHKQAIDCYAKETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRFHAQNLSQVEQDGRSGHGLRSSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRANLIPKEVYILLNWLGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSSKTYGNGYSSNSNGRTDYTGEQSAYQLGQEKENELLCEEAPGMEGFVNCQGTVPSLSIDSQGRNCNTNDSPL
  
Inhibitor
Name:
BDBM50019457
Synonyms:
2-Diethylamino-N-[4-(2-fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-acetamide | CHEMBL42084
Type:
Small organic molecule
Emp. Form.:
C18H23FN4O2
Mol. Mass.:
346.3992
SMILES:
CCN(CC)CC(=O)Nc1c(C(=O)c2ccccc2F)c(C)nn1C
Structure:
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