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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50192829
Substrate
n/a
Meas. Tech.
ChEMBL_1747072 (CHEMBL4181582)
EC50
>10000±n/a nM
Citation
 Lagu, B; Kluge, AF; Fredenburg, RA; Tozzo, E; Senaiar, RS; Jaleel, M; Panigrahi, SK; Tiwari, NK; Krishnamurthy, NR; Takahashi, T; Patane, MA Novel highly selective peroxisome proliferator-activated receptor ? (PPAR?) modulators with pharmacokinetic properties suitable for once-daily oral dosing. Bioorg Med Chem Lett 27:5230-5234 (2017) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50192829
Synonyms:
CHEMBL3958704 | US10188627, Compound 8a
Type:
Small organic molecule
Emp. Form.:
C26H27NO5
Mol. Mass.:
433.4963
SMILES:
CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Structure:
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