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Target
D(2) dopamine receptor
Ligand
BDBM50019721
Substrate
n/a
Meas. Tech.
ChEMBL_59342 (CHEMBL668766)
Ki
25±n/a nM
Citation
 Henning, R; Lattrell, R; Gerhards, HJ; Leven, M Synthesis and neuroleptic activity of a series of 1-[1-(benzo-1,4-dioxan-2-ylmethyl)-4-piperidinyl]benzim idazolone derivatives. J Med Chem 30:814-9 (1987) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DRD2 | DRD2_BOVIN | Dopamine D2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50698.79
Organism:
BOVINE
Description:
P20288
Residue:
444
Sequence:
MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50019721
Synonyms:
1-[1-(6,7-Dimethyl-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidin-4-yl]-5-fluoro-1,3-dihydro-benzoimidazol-2-one | CHEMBL166160
Type:
Small organic molecule
Emp. Form.:
C23H26FN3O3
Mol. Mass.:
411.4692
SMILES:
Cc1cc2OCC(CN3CCC(CC3)n3c4ccc(F)cc4[nH]c3=O)Oc2cc1C
Structure:
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