Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM294014
Substrate
n/a
Meas. Tech.
ChEMBL_1749938 (CHEMBL4184698)
EC50
47±n/a nM
Citation
  TBA Bioorg Med Chem Lett 28:429-436 (2018) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM294014
Synonyms:
(2S)-5-(2-(4-((3-(4-(2- Methoxyethoxy)-2- methylphenyl)-2- methylbenzo[b]thiophen-5- yl)methoxy)phenyl)pent-3-yn-1- yl)-1H-tetrazole | US10106553, Compound 46
Type:
Small organic molecule
Emp. Form.:
C32H32N4O3S
Mol. Mass.:
552.686
SMILES:
COCCOc1ccc(-c2c(C)sc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1 |r,wD:25.25,(-6.91,-6.94,;-6.51,-5.46,;-7.6,-4.37,;-7.2,-2.88,;-8.29,-1.79,;-7.89,-.3,;-8.98,.78,;-8.58,2.27,;-7.09,2.67,;-6.7,4.16,;-7.6,5.4,;-9.14,5.4,;-6.7,6.65,;-5.23,6.17,;-3.9,6.94,;-2.56,6.17,;-2.56,4.63,;-1.23,3.86,;-1.23,2.32,;.1,1.55,;.1,.01,;1.44,-.76,;2.77,.01,;2.77,1.55,;1.44,2.32,;4.1,-.76,;5.44,.01,;6.77,-.76,;6.77,-2.3,;8.24,-2.77,;9.14,-1.53,;8.24,-.28,;4.1,-2.3,;4.1,-3.84,;4.1,-5.38,;-3.9,3.86,;-5.23,4.63,;-6.01,1.58,;-4.52,1.98,;-6.4,.09,)|
Structure:
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